Research Shows Keto May Fight Alzheimer’s

Alzheimer’s disease (AD) is a type of dementia, a chronic neurodegenerative disease. It’s characterized by loss of memory and declining cognition. People with AD typically have problems remembering things and speaking. They may also suffer from mood swings and behavioral changes.1 AD affects individuals over the age of 65, on average. On the molecular level, AD is caused by a loss of neurons and the buildup of amyloid B-peptide-containing plaques in the brain. Interestingly enough, the ketogenic diet may be useful in alleviating some of the symptoms of AD and even reversing it!

Ketones Reverse Alzheimer’s

So, how do ketones help reverse the condition of Alzheimer’s? Researchers looking to ketosis for a potential solution found that it protects the brain from neurodegeneration.2 Specifically, in AD, beta-amyloid levels are high which is actually reduced with a high-fat/low-carb diet. A recent study clarified the link between ketones, amyloid, and cognitive function. The researchers studied this in mice with AD whose neurons were treated with amyloid. Amyloid increased oxidation and disrupted a mitochondrial enzyme complex which ketones actually reversed and helped even more by restoring normal plasticity in the brain and memory performance.3

Support for the Treatment

Not convinced? In a study of 20 people with Alzheimer’s disease who were given either a placebo or medium-chain triglycerides (MCTs, which are highly recommended on the keto diet), ketone levels were measured after a 90 minute waiting period post treatment administration.4 Ketone levels increased which correlated with memory improvements. With that in mind, is it time sensitive? It is thought to be time sensitive in that a ketogenic diet will be more helpful in early treatment of people with Alzheimer’s opposed to treatment years after having the condition.5

A Ketogenic Prescription

A successful ketogenic diet prescription is in the works. Since initial reports indicate it may be helpful in treating AD, further studies are looking into how to appropriately administer the treatment. High-fat diets, medium chain triglyceride supplements, or ketogenic compounds don’t always produce consistent results in all patients. A contributing issue is patient compliance in strict diets or taking supplements.6

Although there are challenges, the ketogenic diet holds promise as a potential treatment for Alzheimer’s. Before you know it, this diet may actually become a real solution to a very serious condition.